Schedule

26th ACT Larson Workshop
Faegre Drinker Offices
2200 Wells Fargo Center, Minneapolis, MN 55402

Click on each date to see for full schedule.

Sun
May 17
4:00-6:00 pm Vendor Display Setup

7:00- 9:00 pm Welcome Reception – Union Rooftop, 731 Hennepin Avenue, Minneapolis

Mon
May 18
7:00 am - 5:00 pm Registration

7:00- 8:00 am Breakfast (provided)/Vendor Display Set-Up

8:00 am Welcome/Announcements

R. Dennis Vigil, Iowa State University, ACT Steering Committee chair  

8:15 am Session I: Fundamentals of Crystallization

Session Chairs: Alpana Thorat (Pfizer) and Christopher Burcham (University of Illinois Urbana-Champagne)

8:20 am Replacement to the Ostwald Rule of Stages

Peter Vekilov, University of Houston

9:10 am From Seashells to Synthesis: Bio-Inspired Approaches for Controlling Crystallisation

Fiona Meldrum, University of Leeds

10:00 am Morning Break

10:20 am Understanding, Modeling and Scale Up of Nucleation

Jan Sefcik, University of Strathclyde

11:10 am Panel Discussion

12:15-1:30 pm Lunch (provided)

1:30 pm Session II: Crystallization Process and Product Design

Session Chairs: Eric Sirota (Merck) and Elena Simone (Politecnico Torino)

1:30 pm Crystallization of Critical Materials - Bridging Fundamental Phenomena and Industrial Impact

Kerstin Forsberg, KTH Royal Institute of Technology

2:20 pm Elucidating Crystallization Pathways in Lead Halide Perovskites

Lara Estroff, Cornell University

3:10 pm Afternoon Break

3:30 pm The Future of Agrochemical Crystallization: From Art to Automated Science

Jennifer Webb, Syngenta

4:20 pm Panel Discussion

6:00-8:00 pm Reception and Banquet (provided)

Blondette, 5th Floor Rand Tower Hotel, 527 S Marquette Avenue, Minneapolis

Tue
May 19
7:15 am - 5:00 pm Registration

7:15- 8:15 am Breakfast (provided)

8:20 am Session III: Crystallization in Digital Space

Session Chairs: Martha Grover (Georgia Tech) and Nandkishor Nere (AbbVie)

8:20 am From Computational Solid-State Chemistry to Molecular Design: Unlocking Opportunities in Modern Drug Discovery and Development

Ahmad Sheikh, AbbVie

9:10 am Opportunities for ML and AI to Advance Crystallization Design in Synthetic Drug Substance Process Development

Dan Griffen, Amgen

10:00 am Morning Break

10:20 am Data-Rich Autonomous Labs for Accelerated Nanocrystal Discovery

Milad Abolhasani, North Carolina State University

11:10 am Panel Discussion

12:15-1:30 pm Lunch (provided)

1:30 pm Session IV: SnapTalks

Session Chairs: Dan Green (GSK) and Mahmoud Mirmehrabi (Solid State Pharma)

1:30 pm High Quality Crystallization Reduces NDMA Formation in Ranitidine HCl

Jon Selbo – Eli Lilly and Company

1:46 pm Engineering the carbonation pathway of magnesium cement towards rapid strength development

Aaron Moment, Soyoung Choi, Logan Ader, Shengwei Dai, Shiho Kawashima – UCLA

2:02 pm Navigating the Amorphous Phase Space: Mechanistic Strategies for Crystallization Risk Mitigation in Spray Dried Dispersions

Suela Jonuzaj – Eli Lilly and Company

2:18 pm Impact of Droplet Evaporation on Polymorphism of Suberic Acid

Sheriff Anofi, Paige Mattucci, Dabrina Dutcher, Timothy Raymond and Ryan Snyder – Bucknell University

2:34 pm Crystallization and Purification of Peptide Fragments

Gaurav Giri, Kennedy Setter, Manish Kelkar, Laurie Mlinar – Abbvie

2:50 pm Break

3:10 pm Particle Engineering in a Continuous Crystallizer Cascade

Giovanni Aprile, Prem K. Reddy, Rajan R. Bhawnani, Cedric Devos, Peter Sagmeister, Aniket Udepurkar, Yuma Miyai, Daanyaal Sajed, Aarna Jindal, Bruno Marco Inzillo, Richard D. Braatz, Allan S. Myerson, Torsten Stelzer – Massachusetts Institute of Technology

3:26 pm High-Pressure Laser Floating-Zone Crystal Growth of Quantum Materials

Xianghan Xu – University of Minnesota

3:42 pm Conquering New Modalities – Process Development for Commercial Macrocyclic Peptides

Carlos Pons Siepermann – Merck

3:58 pm Automation and Algorithms for Crystallization Process Optimization

Samuel Ampofo-Appiah, Matthew A. McDonald – Drexel University

4:14 pm Excipient induced drug phase transformations during pharmaceutical manufacturing

Raj Suryanarayanan – University of Minnesota

4:30 pm A robust CSP platform for predicting crystal polymorphs of pharmaceuticals, agrochemicals, petrochemicals and

Manny Bier, Biswajit Santra, Leif D. Jacobson, Chuanjie Wu, Robert Abel, Richard Friesner, Lingle Wang, Shiva Sekharan – Schrodinger

4:46 pm Finish

5:00 – 6:00 pm Steering Committee Meeting

Workshop participants – dinner on their own

Wed
May 20
7:15 am - 1:00 pm Registration

7:15- 8:15 am Breakfast (provided)

8:20 am Session V: Emerging and Novel Technologies

Session Chairs: Deniz Erdemir (Bristol-Myers-Squibb) and Fredrik Nordstrom (Boehringer Ingelheim)

8:20 am From Solutes in Solution to Solids and Surfaces: Insight into Speciation of Organic Molecules and Their Local Interactions from Advanced X-ray Analysis

Sven Schroeder, University of Leeds

9:10 am High Throughput Nanoscale Crystallization of Small Organic Molecules for SCXRD

Michael Hall, Newcastle University

10:00 am Morning Break

10:20 am Controlled Two-Dimensional Polymerizations

William Dichtel, Northwestern University

11:10 am Panel Discussion

12:00 pm Adjourn, Box Lunches (provided)